abstract：:The search for biological markers of a predisposition towards alcoholism is the result of data indicating that this disorder is genetically influenced. The present paper reviews some methodological considerations important for trait marker research in alcoholism. To date, the most promising results have come from stud...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schuckit MA

更新日期：1986-01-01 00:00:00

abstract：:Study of alcoholic chronic organic brain syndrome may have applicability to the large population of alcoholics with less severe cerebral dysfunction. Brain impairment in alcoholics may be conceptualized as two clinically and neuropathologically distinguishable organic brain syndromes: alcohol amnestic disorder or Kors...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Martin PR,Adinoff B,Weingartner H,Mukherjee AB,Eckardt MJ

更新日期：1986-01-01 00:00:00

abstract：:A logical first place to look in order to identify loci determining behavioral differences between inbred and certain outbred strains of mice is among the proteins expressed in brain. Fourteen mouse brain proteins have been demonstrated to be genetically variant, four of these have been chromosomally mapped and an add...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Goldman D,Crabbe J

更新日期：1986-01-01 00:00:00

abstract：:Urinary and plasma DHPG and MHPG were estimated in patients with MADD and showing DST non-suppression as compared to those with normal suppression. Day and night 12h urine collections and morning plasma samples were analyzed by GC-MS for total MHPG and DHPG and free MHPG levels. Urinary DHPG excretion was significantl...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Warsh JJ,Hasey G,Cooke RG,Stancer HC,Persad E,Jorna T,Godse DD

更新日期：1985-01-01 00:00:00

abstract：:We have examined the effects of postnatal handling of rat pups from Days 1 to 21 on the development of the intracellular, glucocorticoid receptor in the hippocampus, and pituitary transcortin, and corticoid binding globulin in plasma. All animals were sacrificed 10-14h following adrenalectomy and the in vitro receptor...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Sapolsky RM

更新日期：1985-01-01 00:00:00

abstract：:Effective drugs for mental disorders have been found by serendipitous findings not supported by knowledge of psychopharmacology. Drug are assigned labels, such as "antidepressant" without knowledge that such a label delimits the utility of such agents. Many double-blind controlled studies have shown that imipramine ef...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rifkin A,Siris SG

更新日期：1985-01-01 00:00:00

abstract：:Sixteen male Wistar strain rats were trained to have their skin conductance activity recorded through the soles of their hind limbs, and the effects of the intraventricular administration of 6-OHDA (200 micrograms) on this activity were studied. The intact rats showed skin conductance response and its habituation to r...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yamamoto K,Kiyosumi H,Yamaguchi K,Moroji T

更新日期：1985-01-01 00:00:00

abstract：:Many antidepressant drugs inhibit the neuronal uptake of norepinephrine, serotonin, epinephrine and/or dopamine. Some newer antidepressant drugs are highly selective in their ability to inhibit the uptake of one or more of these monoamines. This uptake inhibition, which would be expected to increase the synaptic conce...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fuller RW,Wong DT

更新日期：1985-01-01 00:00:00

abstract：:The adrenergic activation of glycogenolysis in the rat liver is converted from an alpha-1 to a beta-2-receptor mediated event in various conditions associated with cellular dedifferentiation. Short-term incubation of isolated hepatocytes in a serum-free medium results in a similar conversion of the adrenoceptor respon...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kunos G,Ishac EJ,Nador A,Lapchak P

更新日期：1985-01-01 00:00:00

abstract：:Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool befor...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Marcy R,Quermonne MA,Raoul J,Nammathao B,Smida A

更新日期：1985-01-01 00:00:00

abstract：:The sleep pattern and conditions at the time of awakening were investigated by means of polygraphy and tests in 6 healthy adult volunteers following administration of amineptine. The drug was found to increase the number and duration of the REM phases, without affecting the overall sleeping time but reducing sleep lat...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bramanti P,Bianchi L,Benedetto M,Ricci RM,Scribano MA,Di Perri R

更新日期：1985-01-01 00:00:00

abstract：:The term pseudodementia is applied to the range of functional psychiatric conditions such as depression, schizophrenia and hysteria that may mimic organic dementia, but are essentially reversible on treatment. Depression is the commonest cause of pseudodementia in the elderly and is also the commonest treatable condit...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fisman M

更新日期：1985-01-01 00:00:00

abstract：:It has been suggested that protein synthesis and immunological factors play a role in the development of tolerance and dependence to opiates. Interferon (IFN) is known to influence protein synthesis and the immune system. Our and other data suggest that IFN may be an agent that prevents the development of tolerance an...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dafny N

更新日期：1984-01-01 00:00:00

abstract：:Stereoisomers have been used for more than a century to study the role of three-dimensional (spatial) features in biological processes. Configuration and conformation are spatial features of primary interest for effects of drugs. The role of configuration has been studied mainly by comparing effects of optical isomers...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Smith DF

更新日期：1984-01-01 00:00:00

abstract：:Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk. Patients taking these drugs for four months o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lader M

更新日期：1984-01-01 00:00:00

abstract：:The degree to which organisms can exert control over events to which they are exposed has a strong impact on behavior and physiological functioning. Effects caused by the uncontrollability of events that are beyond the organism's control rather than by the events per se have been called learned helplessness effects. T...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Maier SF

更新日期：1984-01-01 00:00:00

abstract：:Apomorphine HCl (Apo) (0.25, 0.5 or 0.75 mg sc), a dopamine (DA) receptor agonist, induced penile erections (PEs) (monitored by mercury strain gauges and continuous recording on paper strip charts) in 7 out of 9 normal subjects and placebo in 1 of these 9 (p less than 0.05). Apo-induced PEs recurred in each of the 6 s...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lal S,Ackman D,Thavundayil JX,Kiely ME,Etienne P

更新日期：1984-01-01 00:00:00

abstract：:In our studies of drug therapy in child psychiatry disorders, we have been using a battery of tests to monitor any effects of medication on the various components of cognitive processing. Our intention was to measure skills required by the children for successful classroom performance. We have used this test battery a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ferguson HB,Simeon JG

更新日期：1984-01-01 00:00:00

abstract：:Opioid analgesics influence the function of a number of neurotransmitter systems including classical neurotransmitters, neuropeptides and endogenous opioids. The role of these interactions in analgesia, tolerance and dependence is reviewed. Opioids inhibit the release of substance P from high threshold primary afferen...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Jhamandas KH

更新日期：1984-01-01 00:00:00

abstract：:The possible interaction of melatonin with the GABAergic system at the receptor level was investigated. The effect of melatonin on the binding of the GABA agonist, [3H]muscimol, in crude synaptic membrane preparations was assayed. In fresh membrane preparations, melatonin increased [3H]muscimol binding in the rat stri...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Coloma FM,Niles LP

更新日期：1984-01-01 00:00:00

abstract：:Haloperidol serum levels were determined by the recently developed radioimmunoassay technique to elucidate the relationship between serum levels and clinical effects and that between serum levels and adverse effects. The serum levels of haloperidol in divided daily doses schedule reached to the steady state more rapid...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Itoh H,Yagi G,Tateyama M,Fujii Y,Iwamura K,Ichikawa K

更新日期：1984-01-01 00:00:00

abstract：:Lithium carbonate appears to inhibit the development of cocaine-induced behavioral sensitization while it does not inhibit the development of amygdala kindling. Lithium chloride did not inhibit kindled seizures. Carbamazepine does not inhibit cocaine-induced motor activity or the development of behavioral sensitizatio...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Post RM,Weiss SR,Pert A

更新日期：1984-01-01 00:00:00

abstract：:Behavioural actions of benzodiazepines have a number of significant characteristics. Anxiolytic effects are demonstrable both clinically and experimentally; in addition, there is excellent evidence for a reinforcing effect of these compounds, and a direct involvement in ingestional responses. This review focusses on t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cooper SJ

更新日期：1983-01-01 00:00:00

abstract：:Characteristics of primary cultures of neurons or of astrocytes are discussed which suggest that such cultures are appropriate models for their in vivo counterparts. Advantages or disadvantages of these cultures for studies of receptor binding are: Neuronal and astrocytic binding can be studied separately. Binding can...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hertz L,Bender AS,Richardson JS

更新日期：1983-01-01 00:00:00

abstract：:Suriclone, a new psychotherapeutic agent chemically unrelated to benzodiazepines or phenothiazines was assessed in a single-blind dose-ranging study to determine its efficacy and safety in out-patients with generalized anxiety disorder. Suriclone was an effective anxiolytic drug at a dose range between 1.2 mg. and 3.6...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lapierre YD,Oyewumi KL

更新日期：1983-01-01 00:00:00

abstract：:1. 15 schizophrenic patients diagnosed according to criteria of I.C.D.-9 were treated with d1-propranolol in a 4 week open study. 2. A fixed dose schedule was followed and a maximum dose of 1920 mg/day was reached by day 17. 3. Results revealed a significant reduction in core schizophrenic symptoms of CPRS & BPRS star...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sethi BB,Dubé S

更新日期：1983-01-01 00:00:00

abstract：:This paper presents the results from a large multicenter study, performed at three clinical research units in the USA. Prior to a three to seven days of placebo washout period, patients were randomly assigned to zimelidine, a potent and selective 5-HT reuptake blocker, amitriptyline or placebo. The scheduled treatment...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Claghorn J,Gershon S,Goldstein BJ,Behrnetz S,Bush DF,Huitfeldt B

更新日期：1983-01-01 00:00:00

abstract：:A major component of opiate reward is derived from a drug action in the ventral tegmental area: (a) rats quickly learn to self-administer morphine directly into the ventral tegmentum, (b) intracranial self-administration into other brain sites is not quickly learned, and (c) narcotic antagonist microinjections into th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bozarth MA,Wise RA

更新日期：1983-01-01 00:00:00

abstract：:We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Simon P,Chermat R,Puech AJ

更新日期：1983-01-01 00:00:00

abstract：:Over a decade of work by Flynn and colleagues has delineated a network of limbic circuits which function to modulate the expression of predatory aggression and defence in the cat, and aspects of this work are reviewed. In particular, Flynn's work revealed a circuit involving the basomedial amygdala which functions to ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Adamec RE,Stark-Adamec CI

更新日期：1983-01-01 00:00:00

abstract：:Monoamine oxidase (MAO) in astroglial primary cultures increased during cell development. The enzyme activity towards type B substrate was further enhanced in cultures treated with 0.25 mM dibutyl cyclic AMP (dBcAMP), although dBcAMP (1 mM) does not effect MAO activity in vitro. It has been estimated that the dBcAMP t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yu PH,Hertz L

更新日期：1983-01-01 00:00:00

abstract：:Five schizophrenic patients (diagnosed using Research Diagnostic Criteria) under treatment with intramuscular fluphenazine decanoate or oral fluphenazine dihydrochloride had serial plasma fluphenazine and plasma prolactin levels determined by a direct radioimmunoassay method. Clinical state was assessed utilizing the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dudley J,Rauw G,Hawes EM,Keegan DL,Midha KK

更新日期：1983-01-01 00:00:00

abstract：:Although ECT is a highly effective treatment for severe depression and other psychiatric syndromes, its mode of action is not known. Recent studies have suggested that effects of ECT on central neurotransmitter receptors may underlie its therapeutic action. The effects of chronically administered electroconvulsive sho...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lerer B,Sitaram N

更新日期：1983-01-01 00:00:00

abstract：:1. U-50,488 is a structurally novel, non-mu opioid. In the present experiments it was compared to the reputed kappa opioid agonists, ketazocine, ethylketocyclazocine and bremazocine as regards analgesic cross tolerance to morphine and U-50,488, antagonism of analgesia by naloxone and MR-2266 (in vivo pA2 determination...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Von Voigtlander PF,Lewis RA

更新日期：1982-01-01 00:00:00

abstract：:1. A double-blind study of the effect of CDP-choline on memory impairment following bilateral ECT was performed on 22 inpatients suffering from endogenous depression. 2. Memory scores were checked after 2 and 4 ECT sessions, and the length of the post-ECT confusional state was also measured. 3. The results show no sta...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ayuso-Gutierrez JL,Saiz-Ruiz J

更新日期：1982-01-01 00:00:00

abstract：:1. A randomized, placebo controlled, double-blind cross-over study was conducted to evaluate the clinical efficacy of the anticholinergic agent, benztropine mesylate (CogentinR) in 29 patients with mild to moderate, idiopathic Parkinson disease. 2. Patients were maintained on a stable, therapeutically optimal dosage a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tourtellotte WW,Potvin AR,Syndulko K,Hirsch SB,Gilden ER,Potvin JH,Hansch EC

更新日期：1982-01-01 00:00:00

abstract：:1. The opiate receptor binding to whole brain synaptic membranes obtained from mice subjected to acute and chronic morphine administration and precipitated withdrawal was investigated. 2. The number of high and low affinity binding sites was significantly higher in morphine tolerant group than in control; acute admini...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sivam SP,Nabeshima T,Ho IK

更新日期：1982-01-01 00:00:00

abstract：:1. Type I risk factor for tardive dyskinesia is defined as a risk leading primarily to a reversible form, while Type II factors to irreversible forms. 2. Central anticholinergic drugs appear as the prototype of Type I drug factor which increased the clinical manifestations of the disorder, but not its overall incidenc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chouinard G,Steinberg S

更新日期：1982-01-01 00:00:00

abstract：:1. The patient population consisting of fifteen patients was divided into three groups, namely: diazepam group, phenobarbital group and placebo group. After three weeks the medicated groups were switched to placebo for a week and the placebo group was given phenobarbital. 2. The parameters to be assessed once a week c...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schwarz E,Kielholz P,Hobi V,Goldberg L,Hofstetter M,Ladewig D

更新日期：1982-01-01 00:00:00

abstract：:1. The investigations in biological factors of childrens' behaviour disorder are becoming increasingly important as their significance in clinical management is being recognized with more precision and clarity. 2. One of such electroencephalographic investigations is finding of some delay or defect in chronological ma...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Singh AN

更新日期：1982-01-01 00:00:00